Radiobiology in Nowadays: Review in the News Trends in Radiopharmacy and in Psychiatric Diagnosis
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Introduction: In Nuclear medicine radiopharmaceuticals or radiobiocomplex are used to obtain images of the human body to recognize alterations in the physiology and to identify metabolic problems. The psychiatric diagnosis of different mental disturbs is nowadays a good resource and a data bank of the obtained images is made to attend the clinic use. Using a mathematical language, the nuclear medicine inform that the obtained image belongs to a psychiatric group of diseases.
Objective: The authors pretend to review the news publications done with radiopharmaceuticals, nuclear medicine and psychiatry to elucidate the applications in these areas.
Methods: It was searched in June 30th 2021, the PubMed database articles published in the last 5 years with the following key-words: nuclear medicine and radiopharmaceuticals and psychiatry as a review and systematic review works.
Results: Then it was founded 38 works in the PubMed database. Only 17 were as a free full text article. It was selected 7 articles that have a mention about medical image diagnostic for psychiatric disorders and the use of radiopharmaceuticals. These were described using the methods, results and conclusions about the research they were proposed.
Conclusions: By the way, the psychiatrics pass by to have information about of mental disease, their classification, prognostic and diagnose suggestions by data bank.
Keywords: Radiobiology, Radiobiocomplex, Nuclear medicine, Radiopharmacy, Psychiatry, Medical image diagnosis, Data bank
In Nuclear medicine radiopharmaceuticals or radiobiocomplex  are used to obtain images of the human body to recognize alterations in the physiology and to identify metabolic problems [2-4]. The use of radiopharmaceuticals in medicine was recommended along the years to diagnostic diseases of the human system .
Radiopharmaceuticals as well as HMPAO , SESTAMIBI , ECD , and others that use 99mTc as a probe to identify the target organs metabolic physiology, and in psychiatric diagnosis they are still used too [9-15]. Other works using FDG could also identify cerebral altered activity [16-18], because FDG with the probe of glucose labelling with 18F as a marker of the metabolic activity of the brain using glucose or the lack of its activity because the neurons are damaged.
The psychiatric diagnosis of different mental disturbs is nowadays a good resource and a data bank of the obtained images is made to attend the clinic use . This data with nuclear medicine imagens has a differential of figures obtained from patients’ brains that could be useful in our days [9-12].
The psychiatry is one of the more needy medical specialties, in terms of complementary examinations, and the cerebral SPECT done with HMPAO could be used to help the clinician in doubt cases. In some cases when we have the association of cerebral SPECT with computed tomography and/or magnetic resonance could precede the mental diseases diagnostic. Using a mathematical language, the nuclear medicine inform that the obtained image belongs to a psychiatric group of diseases (for example, bipolarity, schizophrenia, and others) .
In this work authors pretend to review the news publications done with radiopharmaceuticals, nuclear medicine and psychiatry to elucidate the applications in these areas.
It was searched on June 30th 2021, the PubMed database articles published in the last 5 years with the following key-words: nuclear medicine and radiopharmaceuticals and psychiatry as a review and systematic review works. Then it was founded 38 works that only 17 were as a free full text article. It was selected 7 articles that have a mention about medical image diagnostic for psychiatric disorders and the use of radiopharmaceuticals. These were described using the methods, results and conclusions about the research they were proposed. These findings were presented through tables bellow.
In Table 1 it is analyzed the methods and results presents in 7 articles chosen from the research in PubMed.
In Table 2 it is compared the conclusions obtained in those 7 articles founded.
In nuclear medicine the use of radiopharmaceuticals to diagnostic brain disturbs is well known [1,2,5]. In psychiatry the use of radiobiocomplex to obtain diagnose about behavior findings in disturbed people is still a new approach although there are some data-bank that are used to do the diagnostic [9-12].
All the selected authors in their works used radiopharmaceuticals and nuclear medicine procedures to try to diagnostic and following mental disturbs, it is a beginning of a new way to look the brains commitments that could alter the human health life, and the use of radiopharmaceuticals as a tool to diagnose and follow this disturbs.
Chandra and his collaborators showed the new promising use of PET molecular imaging in the diagnosis of some neurological process . Pet molecular image of the brain involves increase or decrease glucose metabolism.
Other authors empathized the use of PET associated with some radiopharmaceuticals as FDG that it is useful for central nervous system diseases [16-19]. Those are metabolic reasons for the brain function and the use of glucose labelling with 18F is the tool to discover it.
Others discussed the use of radiopharmaceuticals for diagnostic in psychiatry cases like dementia [14,15]. The diagnostic in psychiatry has an advance in the use of this radiopharmaceuticals that could improve images of the brain function discovering the disturbs origin of those diseases.
Although, the methodologies utilized in their works, all are convinced that the nuclear medicine is the way to diagnostic and following the patients with some brain disturbs [13-19], what is not well-determined by the psychiatrist today.
The mental disease tends to be understood as a cerebral disease, to see how the brain works pass by to be a priority, and the perfusion scintigraphy, the way to sustain it.
The use of FDG as a tool to determine metabolic brain function could help the psychiatry about some lesions into the brain that could be caused by metabolic disturbs.
The use of HMPAO radiopharmaceutical that through the haemato-encephalic barrier immediately before the endogenous injection, could be an option more useful for the PET scan studies in mental disturbs that today no causes are described.
By the way, the psychiatrics pass by to have information about of mental disease, their classification, prognostic and diagnose suggestions by data bank.
More research would be done to cover all aspects of diagnostic medicine that could help the psychiatry in the discover of brain function and to treat brain disfunctions.
We thanks to Clínica Serviço de Imagem Médica, that supporting this work.
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