Association of Adiponectin Gene with Metabolic Risk Factors in Postmenopausal Obese Women
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Background: Visceral obesity and insulin resistance (IR) are considered the main features determining the negative cardiovascular profile in metabolic syndrome. Adipose tissue is an active metabolic tissue; it plays a crucial role in the regulation of whole-body metabolic homeostasis. Evidence demonstrates that several adipocyte-derived cytokines are involved in obesity-induced IR.
Objective: The present study investigates visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) adiponectin mRNA levels and their association with metabolic risk factors in postmenopausal obese women.
Method: A case control study was carried out on postmenopausal women (n=68), aged 45-70 year, in which 34 were obese and 34 were non-obese. Blood samples, visceral and subcutaneous adipose tissues were obtained. Adiponectin mRNA levels were measured by Real Time-RT PCR.
Results: The mean (±SEM) serum adiponectin, VAT and SAT adiponectin mRNA levels were significantly lower (p<0.001) in obese than non-obese. However, the present study did not find any significant difference between VAT and SAT adiponectin mRNA levels (p>0.05) either in non-obese or in obese, although in both the cases it was lower in SAT than VAT. The mean glucose and TG levels were significantly (p<0.001) higher, while HDL was lower (p<0.01) in obese than non-obese. Furthermore, VAT adiponectin mRNA also showed significant (p<0.05) and inverse association with TG, while direct association with HDL and both the associations were independent of BMI and waist circumference.
Conclusion: The present study concluded that there is significant association of VAT adiponectin mRNA with TG and HDL suggesting its potential modulatory role in lipid metabolism in postmenopausal obese women.
Keywords: Adiponectin, Adipose tissue, mRNA, SAT, VAT
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