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EBV is very
probably the virus of strict human specificity responsible for the largest
number of chronic pathologies in humans and is thus at the origin of a very
significant morbidity and mortality. But it is above all a shadow fighter,
anxious not to face his enemies frontally, always looking for mechanisms to
overcome the defense systems that are opposed to him by using their own
weapons. This results in great difficulty in his approach and the development
of defensive strategies, which are effective against him. Among the manners to
approach the virus is a very recent one consisting in some way to take the
adversary to his own game; it is the use of non-coding RNAs, as ultimate
epigenetic regulators, whose mechanisms and properties are better and better
identified and able to thwart the plans woven in the shadows by this formidable
virus. Of course, these non-coding RNAs belong on the one hand to the host cell
where they regulate the genes involved in the antimicrobial defense mechanisms,
on the other hand to the virus itself which uses them in order to circumvent
these same defense mechanisms. To solve this equation, we use
nanobiotechnologies allowing the use of ultra-low doses in the context of a
precision medicine combining principles of epigenetic regulation and biomimetic
regeneration with hormesis and its rules. With the help of a few clinical
cases, we will show how Bio Immune(G)ene Medicine - BI(G)MED - is able to
neutralize EBV, whatever the pathology in which the latter is involved, and we
will see that non-coding RNAs really represent a vengeful weapon in our fight
against viruses in general and EBV in particular.
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