2518
Views & Citations1518
Likes & Shares
As described
in Japanese essay, Hojoki which was written by Chomei Kamono at Kyoto around
1200, various disasters such as big fires, earthquakes, relocations of capitals
followed by famines hit Kyoto in Japan. Not only in Japan, all of the countries
in the world have been suffering from the disasters. Recently, natural disasters
are increasing due to global warming. There were three times as many natural
disasters from 2000 through 2009 as there were from 1980 through 1989. Because
tropical-infectious diseases are often disaster-related infectious diseases
(DRIDs), the strategies against the former could be applicable to DRIDs. In
turn, infectious diseases could themselves be regarded as constituting natural
disasters such as HIV and COVID-19. In situations of disasters, it is desirable
if you can identify the pathogen and identify disease severity simultaneously.
Adipstick DNA chromatography assay termed as Single-Tag Hybridization-Printed
Array Strip (STH-PAS) system was developed based on the DNA sequences of
various mosquito-borne diseases. The STH-PAS system was more sensitive in
detecting dengue infection compared to Taqman real-time RT-PCR: for DENV - 1,2
and 3 by one to 2 dilutions higher, and for DENV-4 by 2-4 dilutions higher (European
Journal of Clinical Microbiology & Infectious Disease. 2019 Mar; 38(3): 515-521).
The plasma levels of matricellular proteins including galectin-9 (Gal-9) and
osteopontin (OPN) were found to reflect the disease severities in the dengue
virus and other DIRDs (J Clin Virol. 2013 Dec; 58(4): 635-40) (Thromb Res. 2014
Aug; 134(2): 449-454). Because both proteins have been reported to be
immune-check molecules, their inhibition might enhance the immune system
against pathogens. We found that brefelamide derivatives could inhibit OPN and
other inflammatory molecules synthesis. (Int Immunopharmacol. 2019 Oct; 75: 105831).
Very recently, different derivatives were found to inhibit PD-L1 transcription.
Applications of these agents should be considered as multi-step strategies
against DRIDs.
QUICK LINKS
- SUBMIT MANUSCRIPT
- RECOMMEND THE JOURNAL
-
SUBSCRIBE FOR ALERTS
RELATED JOURNALS
- International Journal of Diabetes (ISSN: 2644-3031)
- Journal of Oral Health and Dentistry (ISSN: 2638-499X)
- Journal of Otolaryngology and Neurotology Research(ISSN:2641-6956)
- International Journal of Internal Medicine and Geriatrics (ISSN: 2689-7687)
- Advance Research on Endocrinology and Metabolism (ISSN: 2689-8209)
- Archive of Obstetrics Gynecology and Reproductive Medicine (ISSN:2640-2297)
- Advance Research on Alzheimers and Parkinsons Disease