Conference Proceedings
Multifaceted Highly Targeted Sequential Multidrug Treatment of Early Ambulatory High-Risk SARS-CoV-2 Infection (COVID-19)
Peter A McCullough*
Corresponding Author: Peter A McCullough MD, MPH, Academic Medical Center, Texas A & M University College of Medicine, USA
Accepted: May 19, 2021 Available Online: May 28, 2021
Citation: McCullough PA. (2021) Multifaceted Highly Targeted Sequential Multidrug Treatment of Early Ambulatory High-Risk SARS-CoV-2 Infection (COVID-19). J Infect Dis Res, 4(S1): 10.
Copyrights: ©2021 McCullough PA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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The SARS-CoV-2 virus spreading across the world has led to surges of COVID-19 illness, hospitalizations, and death.  The complex and multifaceted pathophysiology of life-threatening COVID-19 illness including viral mediated organ damage, cytokine storm, and thrombosis warrants early interventions to address all components of the devastating illness.  In countries where therapeutic nihilism is prevalent, patients endure escalating symptoms and without early treatment can succumb to delayed in-hospital care and death.  Prompt early initiation of sequenced multidrug therapy (SMDT) is a widely and currently available solution to stem the tide of hospitalizations and death.   A multipronged therapeutic approach includes 1) adjuvant nutraceuticals, 2) combination intracellular anti-infective therapy, 3) inhaled/oral corticosteroids and colchicine, 4) antiplatelet agents/anticoagulants, 5) supportive care including supplemental oxygen, monitoring, and telemedicine.  Randomized trials of individual, novel oral therapies have not delivered tools for physicians to combat the pandemic in practice.  No single therapeutic option thus far has been entirely effective and therefore a combination is required at this time.  An urgent immediate pivot from single drug to SMDT regimens should be employed as a critical strategy to deal with the large numbers of acute COVID-19 patients with the aim of reducing the intensity and duration of symptoms and avoiding hospitalization and death.

Keywords: COVID-19, SARS-CoV-2, Ambulatory treatment, Anti-infective, Anti-inflammatory, Anticoagulant, Antiplatelet agent, Antiviral, Corticosteroid, Hospitalization, Mortality, Sequenced multidrug therapy.