2956
Views & Citations1956
Likes & Shares
Carcinogenesis is a multistep process characterized by
alterations in various genetic and epigenetic events. Oral squamous cell
carcinoma is a common oral malignancy that may develop either de novo or from oral potential malignant
disorders as a consequence of multiple molecular and cellular events. An
important hallmark identified for tumor development is the acquired ability of
developing tumors to escape immune control of the body thereby progressing
unhindered and leading to severe morbidity and mortality. The immune system of
the body represents a complex assortment of interacting cells and proteins and
literature data accumulated over the years suggest the development of host
immune response to various human cancers. The role of immune system in human carcinogenesis
is often regarded as a double-edged sword wherein the body’s immune system is
known to nullify the harmful effects of cancer cell proliferation while it may
also promote tumor growth. Various cellular mediators of immunity such as
interferon-γ, mast cells, TNF-α, tumor associated macrophages and eosinophils
were evaluated in OSCC but not much has been proved. One of the important
cellular mediators which also possess therapeutic implications is the family of
interferons. Interferons are a multi-gene family of inducible cytokines having
an important role in cell growth inhibition, modulation of cell differentiation
and in the elimination phase of cancer immuno-editing. Owing to the scarcity of
scientific literature, a comprehensive assessment is required to prove the role
of these immune cells in OSCC. The need of the hour is to identify the
therapeutic potential of immune regulators such as IFN-γ to enable the host to
effectively combat the tumor cell and its associated morbidity. Targeted therapy
aimed at action of IFN-γ against tumor cells should be clinically evaluated as
a treatment regimen to support the standard treatment protocols thereby
reducing morbidity and mortality.
Keywords: Immune system, Oral squamous cell carcinoma, Oral potentially malignant disorders, Immunosurveillance, Interferon
QUICK LINKS
- SUBMIT MANUSCRIPT
- RECOMMEND THE JOURNAL
-
SUBSCRIBE FOR ALERTS
RELATED JOURNALS
- Journal of Spine Diseases
- Journal of Clinical Trials and Research (ISSN:2637-7373)
- Dermatology Clinics and Research (ISSN:2380-5609)
- International Journal of Surgery and Invasive Procedures (ISSN:2640-0820)
- International Journal of AIDS (ISSN: 2644-3023)
- Journal of Renal Transplantation Science (ISSN:2640-0847)
- Journal of Immunology Research and Therapy (ISSN:2472-727X)